Clean living is at the heart of the s.i.m.p.l.e 7 nutrition approach.  Well- researched articles will help keep you informed with the connection between toxins and the relationship with your health.   

Why all the talk about MTHFR? Why Should I Care?

MTHFR Genotyping,                                                               Single-Nucleotide Polymorphism                     


MTHFR is an enzyme responsible for converting 5,10-methylenetetrahydrofolate to the product 5-methyltetrahydrofolate.  It is involved in the metabolism of folate and homocysteine. The product of the reaction catalyzed by MTHFR converts homocysteine (a potentially toxic amino acid) to methionine (a useful and necessary amino acid).

Why is MTHFR Genotyping Important?

  • Certain mutations in the gene coding for MTHFR produce an enzyme that has reduced activity.
  • Genetic link to poor detoxification
  •  Reduced activity can lead to elevated levels of homocysteine (a.k.a. hyperhomocysteinemia), especially when folate levels are low.
  • High homocysteine (>13umol/L) may double the risk of developing illness or complications.
  • MTHFR genotyping can provide information about potential causes of elevated homocysteine and approaches for addressing it.
  • Based on MTHFR and homocysteine results, physicians can develop dietary and medical recommendations - increased intake of folate alone or in combination with vitamins B6 and B12 are recommended.
  • Based on results, recommendations for methotrexate dosage can be adjusted.  

 Risks Associated with MTHFR Variants (High Homocysteine):

  •   ADHD
  •   Bipolar/
  •   Chronic Fatigue
  •   Fibromyalgia
  •   Tongue/Thin Hair/Fingernails
  •   Gut Barrier Dysbiosis (high ammonia levels)
  •   PMS
  •   Estrogen Dominance
  •   Cancer (Adenoid Carcinoma Cells)
  •   Infertility
  •   PCOS/High Testosterone
  •   Cardiovascular Disease
  •   Cerebral Vascular Disease (Stroke)
  •   Venous and Arterial Thrombosis
  •   Methotrexate Toxicity for Cancer Therapy

Who Should be Tested?

  • Those with poor metabolism of caffeine, tea, chocolate, etc.
  • Those with high zino estrogen levels
  • Those with high homocysteine levels.
  • Those who have a familial history of cardiovascular disease, stroke or thrombosis.